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8/21/2014 1:59 A.M. ET

Bryant regains Minor League homer lead with No. 41

Cubs' No. 1 prospect Kris Bryant retook sole possession of first place in the Minor League home run race Wednesday with a two-run home run in the third inning.

Bryant's two-run blast, his first since last Thursday and 41st of 2014, wasn't enough to power Triple-A Iowa to a victory, however, as Reno scored the final 10 runs of the game and won, 11-4.

Bryant, ranked No. 3 on MLBPipeline.com's Top 100 Prospects list, has hit 41 home runs between Iowa and Double-A Tennessee this season. He holds a slim edge over Rangers No. 1 prospect Joey Gallo, who has hit 40 home runs. Bryant's total is the highest by any Minor Leaguer since 2008, when Marlins farmhand Dallas McPherson bashed 42 in 127 games at Triple-A Albuquerque.

Bryant finished Wednesday's game 2-for-3 with a walk. In 59 games since getting promoted to Iowa, the 22-year old is hitting .312/.426/.663 with 19 home runs.

Bryant's home run Wednesday marked another milestone: It was his 50th home run as a professional. In 163 games since the Cubs made him the second overall pick in the 2013 First-Year Player Draft, he is hitting .336/.432/.685 with 137 RBIs and 131 runs.

Teddy Cahill is a reporter for MLB.com. Follow him on Twitter at @tedcahill. This story was not subject to the approval of Major League Baseball or its clubs.